Mupirocin Ointment: A Comprehensive Guide to This Topical Antibiotic

what is mupirocin ointment used for

Mupirocin ointment is a versatile and potent topical antibiotic commonly used for the treatment and prevention of various skin infections. Derived from the bacterium Pseudomonas fluorescens, mupirocin is known for its broad-spectrum activity against gram-positive bacteria, including strains resistant to other antibiotics.

This powerful medication has become a mainstay in modern dermatology, providing effective relief from conditions such as impetigo, minor skin wounds, and even methicillin-resistant Staphylococcus aureus (MRSA) infections. In this article, we will explore what is mupirocin ointment used for, its mechanism of action, and important considerations for its safe and appropriate use.

What is Mupirocin ointment?

Mupirocin ointment is a topical antibiotic used to treat and prevent various skin infections caused by gram-positive bacteria, including impetigo, minor skin wounds, and certain MRSA infections.

How does Mupirocin ointment work?

Mupirocin ointment works by inhibiting bacterial protein synthesis, which is essential for the growth and survival of bacteria. It specifically targets an enzyme called isoleucyl-tRNA synthetase, which is responsible for attaching isoleucine, an amino acid, to its corresponding transfer RNA (tRNA) during protein synthesis.

By binding to this enzyme, mupirocin prevents the formation of isoleucyl-tRNA, thereby disrupting the protein synthesis process. As a result, the bacteria are unable to produce vital proteins and ultimately stop growing and multiplying. This action allows the body’s immune system to combat the infection more effectively, ultimately clearing the infection.

What is Mupirocin ointment used for?

Mupirocin ointment is used for treating and preventing various skin infections caused by gram-positive bacteria. Some common uses include:

  • Impetigo 

A highly contagious skin infection characterised by red sores, often affecting the face, arms, and legs, primarily in children. Mupirocin ointment is effective against the bacteria responsible for impetigo, such as Staphylococcus aureus and Streptococcus pyogenes.

  • Minor skin wounds 

Mupirocin can be applied to minor cuts, abrasions, or burns to prevent bacterial infections and promote healing.

  • Methicillin-resistant Staphylococcus aureus (MRSA) infections 

Mupirocin ointment can be used to treat certain skin infections caused by MRSA, a type of bacteria resistant to many common antibiotics.

  • Infected skin conditions 

Mupirocin may be prescribed for other skin infections, such as folliculitis, cellulitis, or infected eczema.

  • Nasal decolonization 

In some cases, mupirocin may be used as a nasal ointment to eliminate Staphylococcus aureus bacteria from the nostrils, reducing the risk of infection in patients undergoing surgery or those with weakened immune systems.

What are the side effects of Mupirocin ointment?

While most people tolerate mupirocin ointment well, some individuals may experience side effects. The most common side effects are usually mild and may include:

Burning, stinging, or itching at the application site 

These sensations are generally temporary and subside as the body adjusts to the medication.

Redness or irritation 

Some people may experience skin redness or irritation where the ointment is applied.

Dryness or peeling 

The treated area may become dry or peel, especially with prolonged use.

Less common but potentially more serious side effects include:

Allergic reactions 

In rare cases, some people may have an allergic reaction to mupirocin, which may cause symptoms like rash, hives, itching, difficulty breathing, or swelling of the face, lips, or tongue. If you suspect an allergic reaction, stop using the ointment and seek immediate medical attention.

Severe skin irritation 

If you experience extreme redness, burning, or blistering of the skin after applying the ointment, discontinue use and consult your healthcare provider.

Secondary infections

Prolonged use of mupirocin may lead to the overgrowth of resistant organisms, including fungi, which can cause secondary infections. If you notice new or worsening symptoms, consult your healthcare provider.

Is mupirocin ointment safe to use during pregnancy or breastfeeding?

Mupirocin ointment is generally considered safe to use during pregnancy and breastfeeding. However, it is always best to consult with your healthcare provider before using any medication during pregnancy or while breastfeeding.

Pregnancy: Studies have not shown any increased risk of harm to the developing fetus when mupirocin is used during pregnancy. Nevertheless, it should be used only if the potential benefits outweigh the risks, as determined by your healthcare provider.

Breastfeeding: Mupirocin is not absorbed systemically in significant amounts when applied topically, which means that it is unlikely to pass into breast milk and affect the nursing infant. However, to minimize potential exposure, avoid applying the ointment to the breast area or areas where the infant may come into direct contact with it.

How should mupirocin ointment be stored?

To ensure the effectiveness and safety of mupirocin ointment, it is important to store it properly. Follow these storage guidelines:

  1. Keep the ointment at room temperature, ideally between 20°C to 25°C (68°F to 77°F). Avoid exposing it to extreme temperatures, such as freezing cold or excessive heat.
  2. Store the ointment in its original container, tightly closed to protect it from air and moisture.
  3. Keep the medication out of the reach of children and pets to prevent accidental ingestion or misuse.
  4. Do not use the ointment past its expiration date, which can be found on the packaging or container. Expired medication may lose its effectiveness or become harmful.
  5. Dispose of any unused or expired medication properly. Do not flush it down the toilet or pour it down the drain. Consult your pharmacist or local waste disposal company for information on proper disposal methods.

By following these storage guidelines, you can help maintain the quality of mupirocin ointment and ensure its safe and effective use.


Q1: Can mupirocin ointment treat acne?

Ans: Mupirocin isn’t specifically designed to treat acne, but it may help with acne caused by bacterial infections.

Q2: Can I use mupirocin for diaper rash?

Ans: Consult your healthcare provider before using mupirocin on diaper rash, as the cause may not be bacterial.

Q3: Can mupirocin ointment be used on pets?

Ans: Mupirocin may be prescribed for pets by a veterinarian, but don’t use human formulations without consultation.

Q4: How long should I use mupirocin ointment?

Ans: Follow your healthcare provider’s instructions, typically 5-10 days, depending on the infection severity.

Q5: Is mupirocin ointment effective against all bacteria?

Ans: Mupirocin is mainly effective against gram-positive bacteria; it is not as effective against gram-negative bacteria.